US $300, UK £175 * – single user license – online fulfillment
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Dose-Effect Analyzer for Single and Multiple Drugs
CalcuSyn Version 2.0 is the definitive analyzer of combined
drug effects, able automatically to quantify phenomena such
as synergism and inhibition. Mixed drug treatment is becoming
common in the treatment of cancer, AIDS etc, and CalcuSyn is
the most widely used software for establishing efficacy in this
field. It performs multiple drug dose-effect calculations using
the Median Effect methods described by T-C Chou and P. Talalay
(Trends Pharmacol. Sci. 4, 450-454).
CalcuSyn can easily be integrated with other software. Data can
be entered via the keyboard or file import either into the grid
or directly into the analysis engine. When the grid is used, data
can be processed through wizards which make the software easily
accessible to new users.
Data can be processed both for individual drugs and for constant-ratio
or non-constant-ratio combinations of drugs. CalcuSyn automatically
graphs the data and produces reports giving summary statistics on
all drugs plus detailed analysis of drug interactions including the
Combination Index and EDx (for any value of x). Estimates of accuracy
of EDx and CI can be calculated with Monte Carlo simulations or by
a highly accurate algebraic estimation algorithm. The plots drawn
by CalcuSyn include dose-effect, median-effect, isobolograms and
CI-effect. All data and results are easily accessible by mouse-click
on the contents tree.
CalcuSyn Version 2.0 has Undo and Redo tools. There are flexible
arrangements for printing of results and graphs and their export to
spreadsheets, wordprocessors, graphics packages etc. A comprehensive
manual is supplied as .pdf with the software and there is a detailed Help file.
These give a thorough account of the theoretical basis of the analysis
methods including the statistical treatment of results. Already used
in hundreds of academic labs and pharmaceutical companies, CalcuSyn
is indispensable for the study of drug mixtures.
* Single user license US $300/ UK £175
5 user license US $900/ UK £525
10 user license US $1500/UK £875
The above prices are for online fulfillment only and include user manual as .pdf
An additional charge of $90/£50 is made for supply of hard copy (CD) if required